Which of the following types of insulin should not be mixed in the same syringe with other insulins?

Long-acting insulin analogs should not be mixed in the same syringe with other insulins because they have a unique formulation and mechanism of action that is designed to provide a consistent and prolonged effect throughout the day. Mixing them with other types of insulins, such as short-acting or intermediate-acting insulins, can alter their pharmacokinetics, potentially resulting in unpredictable blood glucose control and inconsistent therapeutic outcomes.

Maintaining the integrity of long-acting insulin is crucial for proper diabetes management, as these insulins are tailored to release insulin gradually over a prolonged period. Using them in combination with different insulins could disrupt this carefully designed release pattern and lead to an increased risk of both hypo- and hyperglycemia.

In contrast, short-acting, intermediate-acting, and rapid-acting insulins can generally be combined, as their mechanisms and pharmacological profiles allow for mixing without compromising effectiveness. This practice is common in diabetes management, enabling patients to achieve tailored blood glucose control more efficiently.