Which of the following is a rare but serious adverse effect of lorcaserin therapy?

Lorcaserin, a medication primarily used for weight management, can potentially lead to serotonin syndrome, which is a rare but serious adverse effect. This condition arises when there is an excess of serotonin in the brain, often due to the concurrent use of medications that affect serotonin levels or from high doses of serotonergic agents. Symptoms may include confusion, agitation, rapid heart rate, dilated pupils, muscle rigidity, and in severe cases, can progress to life-threatening complications.

The association of lorcaserin with serotonin syndrome is particularly significant because its mechanism involves modulation of serotonin receptors. Therefore, healthcare providers must be vigilant for signs of this syndrome in patients taking lorcaserin, especially if they are also prescribed other medications that increase serotonin levels, such as certain antidepressants.

While high blood pressure, liver damage, and kidney failure are all potential concerns with various medications, they are not specifically linked to lorcaserin in the same way that serotonin syndrome is. High blood pressure is not commonly reported as a direct adverse effect of lorcaserin, and while liver and kidney issues can arise from various medications, they are not characteristically associated with lorcaserin use. Understanding the specific risk of serotonin syndrome is crucial for safe patient management when using lorcaserin.